Lipotoxicity in the heart.

Protective Effects of Linoleic Acid against the Cytotoxicity of Palmitic Fatty Acid in Rat Cardiomyocytes

Background & Aims: Lipotoxicity is the process through which accumulation of lipid intermadiates leads to cellular dysfunction. The worldwide prevalence of cardiovascular diseases has been increased dramatically due to lipotoxicity. According to the peformed studies, saturated and unsaturated fatty acids differ significantly in their contributions to lipotoxicity. It has been r...

Ameliorative Role of Palmitoleic Acid on Palmitate Induced Lipotoxicity in the Rat Cardiomyocytes

Background: Co-supplementation of unsaturated fatty acids (FAs) with saturated FAs may decrease the adverse effects of saturated FA-induced lipotoxicity. The objective of the present study was to evaluate the effect of palmitoleic acid (unsaturated fatty acid) on palmitic acid (saturated fatty acid) induced lipotoxicity criteria in the primary culture of adult rat cardiomyocytes. Methods: Ce...

Lipotoxicity in cardiac and skeletal muscle

Lipotoxicity is defined as the untoward consequences of the accumulation of excess lipid in non-adipose tissue. Fatty acids are an important substrate for myocyte metabolism, yet mismatch of cellular uptake and utilization results in lipid accumulation that is clearly detrimental. Within the myocyte, lipotoxicity can lead to cellular dysfunction, resulting in defective contraction or relaxation...

Lipotoxicity in myocardial infarction and heart failure. Importance of endogenous lipoproteins for cardiac function, structure and arrhythmias

Lipotoxicity in type 2 diabetic cardiomyopathy.

As obesity and type 2 diabetes are becoming an epidemic in westernized countries, the incidence and prevalence of obesity- and diabetes-related co-morbidities are increasing. In type 2 diabetes ectopic lipid accumulation in the heart has been associated with cardiac dysfunction and apoptosis, a process termed lipotoxicity. Since cardiovascular diseases are the main cause of death in diabetic pa...

Fatty old hearts: role of cardiac lipotoxicity in age-related cardiomyopathy

Age-related cardiomyopathy accounts for a significant part of heart failure cases. Imbalance of the energetic equilibrium of the heart along with mitochondrial dysfunction and impaired β-adrenergic receptor signaling contributes in the aggravation of cardiac function in the elderly. In this review article, studies that correlate cardiac aging with lipotoxicity are summarized. The involvement of...